Motor Neuron Disease

Here is the first book to provide a comprehensive overview of the clinical, pathological, and research aspects of motor neuron disease (MND). The text contains all essential features of the anatomy, physiology, pharmacology and toxicology of the motor system, a full description of MND and its variants, as well as historical developments and a review of the current concepts and controversies. This book comes at a time of increasing interest in neurodegenerative disorders and MND in particular. It will prove a key reference book with an integrated overview of the field, and will be indispensable to practicing neurologists, researchers, and all those with an interest in MND.

Zusammenfassung
"This book is worthwhile to every neurologist and particularly those interested in ALS. It is an interesting book to everybody involved in research on motor neuron diseases. it certainly is one of the better volumes on MND available." Acta Neurologica Belgica

Inhalt
Contents: Motor Neuron Disease: The Clinical Syndrome. Epidemiology of Motor Neuron Disease.- Familial Motor Neuron Disease.- Pathology of Motor System Disorder. The Pathology of Motor Neuron Disease. Alternative Approaches to the Pathology of Motor Neuron Disease. The Molecular Pathology of Motor Neuron Disease. Neurochemistry of Motor Neuron Disease.- Calcium and Aluminium in the Chamorro Diet: Unlikely Causes of Alzheimer-Type Neurofibrillary Degeneration on Guam.- Toxicology of Motor Systems.- Theories of Causation.- Somatic Motoneurons and Descending Motor Pathways. Limbic and Non-limbic Components.- Neurophysiological Changes in Motor Neuron Disease.- Clinical Pharmacology of Motor Neurons.- The Management of Motor Neuron Disease.- Clinical Trial Methodology.- New Therapeutic Approaches: Rationale and Results. Living with Motor Neuron Disease.