Muscle Biopsy

In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.

Highly Commended, RSM Awards 2007
Highly Commended, Basic and Clinical Sciences, BMA Awards 2007
In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.

Inhalt
Section 1 The Biopsy: Normal and Diseased Muscle 1. The procedure of muscle biopsy 2. Histological and histochemical stains and reactions 3. Normal muscle 4. Definition of pathological changes seen in muscle biopsies 5. Ultrastructural changes in diseased muscle 6. Immunohistochemistry 7. How to read a biopsy Section 2 Pathological Muscle: Individual Diseases 8. Classification of neuromuscular disorders 9. Neurogenic disorders 10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy 11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies 12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies 13. Muscular dystrophies and allied disorders IV: Emeryf{Driefuss muscular dystrophies and Bethlem myopathy 14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy 15. Congenital myopathies 16. Myofibrillar myopathies 17. Metabolic myopathies I: glycogenoses 18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies 19. Endocrine disorders 20. Ion channel disorders 21. Myasthenic syndromes 22. Inflammatory myopathies 23. Toxic and drug-induced myopathies Russell Lane, Charing Cross Hospital Appendix 1. Glossary of commonly used terms References Index