Myb Transcription Factors: Their Role in Growth, Differentiation and Disease

This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.

Inhalt
Evolution of Myb Proteins.- Drosophila Myb.- Essential And Diverse Roles For C-Myb Throughout T Cell Development.- Potential Roles For C-Myb Thoughout Early Lymphocyte Development.- Involvement Of C-Myb In Red Cell And Megakaryocyte Development.- C-Myb As A Key Player In The Control Of Myeloid Cell Differentiation.- Does C-Myb Have A Role In Haemopoietic Stem Cells And Multilineage Progenitors?.- A-Myb In Development And Cancer.- B-Myb: A Highly Regulated Member Of The Myb Transcription Factor Family.- Regulation Of Mammalian Myb Gene Expression.- The C-Myb Dna Binding Domain.- Myb Partnerships.- Target Genes Of V-Myb And C-Myb.- The Microarray Big Bang.- The V-Myb Oncogene.- C-Myb And Leukaemogenesis.- The Involvement Of Myb In Vascular Injury.- Repression Of Matrix Gene Expression By B-Myb.- The Role Of C-Myb In Gastrointestinal Tract Development And Carcinogenesis.- C-Myb And Creb Function In Adult Neurogenesis.- The C-Myb Gene: A Rational Target For Treatment Of Human Diseases.