N-acetyl cysteine and L-carnitine effect on CCl4-hepatotoxicity

Present work aimed to evaluate the protective effect of L-carnitine and/or N-acetyl cysteine (NAC) on CCl4-hepatotoxicity. Male albino rats were classified into 8 groups. Group I: normal control group. Group II: treated with L-carnitine. Group III: treated with NAC. Group IV: treated with L-carnitine and NAC. Group V: received CCl4 and served as cirrhotic control group. Group VI: treated with L-carnitine and CCl4. Group VII: received CCl4 and treated with NAC. Group VIII: treated with L-carnitine, NAC and received CCl4. Samples are collected and parts of the livers are preserved for histology. Results showed that treatment with CCl4 induced a significant increase in serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities, plasma sialic acid, total bilirubin, nitrite levels, and liver lipid peroxide content. Also, it induced a significant reduction in plasma albumin level, liver total protein, glutathione, and vitamin C contents. In the present study, it could be noticed (from the treatment with L-carnitine and NAC) that there were pronounced improvements in all studied parameters. We recommend a collective combination of L-carnitine and NAC.

Autorentext

Dr. Moustafa Fathy has obtained his PhD degree in Biochemistry (Stem Cells) in 2010. He has worked in Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan and in Biochemistry Department, Faculty of Pharmacy, Minia University, Egypt. He is the author of several published articles.