Nano- and Microfabrication Techniques in Drug Delivery

New materials and manufacturing techniques are evolving with the potential to address the challenges associated with the manufacture of medicinal products that will teach new tricks to old drugs. Nano- and microfabrication techniques include manufacturing methods such as additive manufacturing, lithography, micro-moulding, spray drying, and supercritical fluids among many others. The increasing resolution of new techniques allow researchers to produce objects with micrometric resolutions. This book follows a consecutive order, beginning with a background in the current field and limitations in the manufacturing of different pharmaceutical products, moving on the classification of each method by providing recent examples, and future prospective on a variety of traditional and new Nano and microfabrication techniques. A focus on the materials used to prepare these systems and their biocompatibility, including applied topics such as clinical applications and regulatory aspects also covered, offering the reader a holistic view of this rapidly growing field.

Brings together technical, clinical, regulatory and industrial perspectives Provides future prospective and includes the potential clinical applications of nano/microfabrication technologies Appeals to a broad readership, such as materials scientists, pharmaceutical engineers, clinicians and regulatory experts

Autorentext

Dimitrios Lamprou (Ph.D., MBA) is Professor (Chair) of Biofabrication and Advanced Manufacturing at Queen's University Belfast. Prof Lamprou lab is applying Nano and Microfabrication Techniques in the Manufacturing of Drug Delivery Systems, Medical Devices & Implants. He has trained in multidisciplinary areas, worked in projects across disciplines, and in first class laboratories in a number of countries. To date, he has over 130 peer-reviewed publications in leading international journals and over 350 conference abstracts, and has over 130 Oral Talks in the area of Nano/Microfabrication.

Inhalt

1. Conducting polymers as drug release systems.- 2. Electrospinning for drug delivery applications.- 3. Melt-electrospinning and electrowriting for pharmaceutical and biomedical applications.- 4. Pharmaceutical Spray Drying.- 5. Vat photopolymerization 3D printing for drug delivery applications.- 6. Semi-solid extrusion 3D printing for the development of dosage forms for special patient groups.- 7. Binder-Jetting Powder bed 3Dprinting for the fabrication of drug delivery systems.- 8. 3D printing for localized cancer therapy.- 9. 4D Printing in Pharmaceutics & Biomedical Applications.- 10. Lithography in Drug-Delivery.- 11. Micro-moulding and its application to drug delivery.- 12. Supercritical Fluids: A Promising Technique in Pharmaceutics.- 13. Microfluidics as a tool for the synthesis of advanced drug delivery systems.- 14. Nanofluidic Technologies for Drug Screening and Drug Delivery.- 15. Nanoparticles at the stage of clinical trials.- 16. Nasal drug delivery systems for thetreatment of diseases of the central nervous system and tuberculosis.- 17. Regulatory aspects and barriers in using ground-breaking technologies.