NANOPARTICLES WITH THE AGGREGATION-INDUCED EMISSION EFFECT: PROPERTIES AND APPLICATIONS

Photodynamic therapy (PDT) is a method of the treatment of localized cancers, based on a photochemical reaction between a light-activated molecule or photosensitizer (PS), light, and molecular oxygen. Correct choice of PS is of fundamental importance for PDT efficacy. Despite numerous studies in this field, most known PS have some drawbacks, e.g. lack of specificity and aggregation in aqueous media. Consequently, the search for an ideal PS is essential for further development of PDT. Here we review classification and analyze main featuresof different generations of PS and describe the mechanisms of their action. Various methods of targeted delivery of PS to tumor cells are discussed. The advantages of PS nanoparticles with the effect of aggregation-induced emission (AIE) over the classic photosensitizers are presented. A possibility of practical application of such light-emitting structures in cancer phototherapy is shown.

Autorentext

Irina Korotkova - Ph. D., Profesora; Tamara Sakhno - Dr., Profesora del Departamento de Biotecnología y Química de la Academia Agraria Estatal de Poltava, Poltava, Ucrania.Anatolii Semenov - Profesor asociado del Departamento de Productos Básicos, Biotecnología, Pericia y Aduanas de la Universidad de Economía y Comercio de Poltava, Poltava, Ucrania.