Nanosuspension Formulation for the Management of Hypertension

Hypertension is one of the primary risk factors for heart disease and stroke, the leading causes of death worldwide. Telmisartan is BCS class II, anti-hypertensive drug.The aim of present work was to develop a Telmisartan nanosuspension for faster onset of action which is essential in hypertension condition. In the present work nanosuspension is prepared by media milling method. Zirconium oxide beads are used as milling media. The optimization was done using 3level3 factor full factorial design.The optimized batch shown particle size is 356 nm,Zeta potential -8.3 and % drug release after 10 min is 64.20%.

Autorentext

Dr.Vikram M. Pandya is an Associate Professor at B.S.Patel Pharmacy College, Linch-Mehsana -384 435, Gujarat, India. He has more than 11 years of academic and Industrial experience, has published 30 research and review papers in various international and national journals. Dr. Pandya has guided 17 M.Pharm students for research work.