Natural Hosts of Siv

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.

Autorentext
Aftab Ansari, Ph.D. Dr. Aftab A. Ansari, Professor, Department of Pathology and Laboratory Medicine, Room 2309 WMB, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USAPh.D., University of Arizona, Tucson, Arizona, 1970 M.S., University of California, Los Angeles, CA, 1967 M.S., University of Karachi, Karachi, Pakistan, 1963 B.S., University of Karachi, Karachi, Pakistan, 1961 1981-present Senior Consultant, Naval Medical Research and Development Command, Bethesda, Maryland1985-Present Professor, Department of Pathology and Laboratory Medicine, Emory University1999-present Scientific Advisor, U.S. Naval Medical Research Unit #2, Jakarta, Indonesia.2002-present Scientific Advisory Board, One World Health, San Francisco, CA.2001-2008 Scientific Advisory Board, Lipid Sciences, Inc. Pleasanton, CA.2005-present Scientific External Advisory Board member, CAHDR, Meharry Medical College, Nashville, TN2008-present Scientific Advisory Board, SMART Technologies, Inc., Rehovot, Israel2007-present Member, FDA Expert Panel, FDA Center for Devices and Radiological Health (CDRH), SGE, Deptt. Of Health & Human Services, Immunology Devices PanelProfessor Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USAChief, Division of Microbiology and Immunology, Yerkes National Primate Research Center Georgia Research Alliance Eminent Scholar in Comparative Pathology, Emory University

Klappentext
Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.

Inhalt

1. Overview
   Aftab Ansari and Guido Silvestri
   
   2. Historical perspective
      Preston Marx
   3. SIV infections in the wild
      Cristian Apetrei and Martine Peeters
   4. Virology of SIVs
      Frank Kirchhoff
   5. SIV infection of chimpanzees
      Jonathan Heeney, Edward James Donald Greenwood and Fabian Schmidt
   6. Pathology of acute & chronic infection
      Francois Villinger and Sanjeev Gumber
   7. Mucosal immunity
      Jason Brenchley
   8. Innate immunity
      Steven E. Bosinger and R. Keith Reeves
   9. Humoral immune responses
      Cynthia Ann Derdeyn and Reinhard Kurth
   10. Cellular immune responses
       Amitinder Kaur
   11. Chronic immune activation
       Donald Sodora
   12. Pattern of infected cells
       Mirko Paiardini and Thomas Howerton Vanderford V
   13. Viral transmission
       Ivona Pandrea and Ann Chahroudi
   14. Genetics of the host
       Lutz Walter
   15. The different modes of HIV/SIV control in monkeys and humans
       Lisa Chakrabarti
   16. Humans resembling natural hosts
       Amalio Telenti and Paul McLaren
       Epilogue: Implications for HIV infection
       Aftab Ansari and Guido Silvestri