Natural Products as Source of Molecules with Therapeutic Potential

This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios.

Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

Presents chapters written by respected international experts from different research fields Covers all aspects of research on drugs from natural products Explains strategic methods to obtain medicinal agents Provides illustrative and current practice examples

Autorentext

Valdir Cechinel Filho is a Professor/researcher at the Postgraduate Program (M/D) in Pharmaceutical Sciences of the University of Vale do Itajaí (UNIVALI) in Santa Catarina, Brazil. He has experienced in the field of Organic Chemistry, focusing on the following topics: bioactive natural products, synthesis of molecules of biological interest, and investigation of the relationship between chemical structure and biological activity. Editor of six books, over twenty contributed chapters and over 300 papers and reviews, besides 12 patents. In 2017, he received the highest Commendation of Academic Merit of the Council of Rectors of Brazilian Universities (CRUB) for his contribution to the Brazilian Higher Education. In March 2018, he became President of the Foundation UNIVALI and Rector of UNIVALI, with a mandate to head the institution until 2022.

Inhalt
Chapter 1- Medicinal Plants and Phytomedicines.- Chapter 2- Plant Product With Antifungal Activity: from Field to Biotechnology Strategies.- Chapter 3- Liquid Chromatography for Plant Metabolite Profiling in the Field of Drug Discovery.- Chapter 4- Functional Foods as Source of Bioactive Principles: Some Marked Examples.- Chapter 5- The Role of Flavonoids as Modulators of Inflammation and on Cell Signaling Pathways.- Chapter 6- Current Approaches to Isolation and Structural Elucidation of Active Compounds from Natural Products.- Chapter 7- Syntheses of Asymmetrically Substituted Pyrans of Natural Origin.- Chapter 8- Natural Products as Sources of Anticancer Agents: Current Approaches and Perspectives.- Chapter 9- Virtual Screening for the Discovery of Active Principles from Natural Products.- Chapter 10- Current Regulatory Environment of Herbal Medicinal Products in the European Union.- Chapter 11- Development and Use of Polymeric Nanoparticles for the Encapsulation and Administrationof Plant Extracts.- Chapter 12- NMR Identification of Biologically Active Natural Products: Strategies and Challenges.- Chapter 13- Herbal Medicine and Public Health Care: Current and Future Challenges.