Natural & synthetic 1-Phenylnaphthalene lignans: Immunomodulation

1-Phenylnaphthalene and Pericarbonyl lactone lignans are synthesized by green chemistry and the lignans having similar 1-Phenylnaphthalene skeleton are extracted from two plants-Ruta graveolens Linn. and Jatropha gossypifolia Linn using soxhlet assembly.These natural and synthetic lignans were then tested for their immunomodulatory potential. Starting with -benzoyl propionic acid and aryl aldehydes, -arylidine- -phenyl- , , -butenolides were synthesized. The lactone ring of butenolides is opened to get the keto acid i.e. -arylidine- -benzoyl propionic acid. Cyclization of above keto acid as well as its derivatives with sulphamic acid catalyst under microwave radiation ultimately lead to 1-Phenylnaphthalene systems. The immunomodulatory activity of the 1-Phenylnaphthalene systems is studied by the two methods Spleen cell proliferation and Effect on serum immunoglobulins . It is found to be quite significant in both synthetic compounds as well plant extracts. The findings suggest that 1-Phenylnaphthalene lignans can positively modulate the immunity of the host.

Autorentext

Dr.Mrs.T.Chaudhari is Ass.Professor of Chemistry in Priyadarshini Polytechnic and an active member of Indian Science Association. Dr Mrs.S.Deo and Dr.Mrs.F.Inam are the Professors, Institute of Science, Nagpur and guided more than 15 research students. The author and co authors have published several papers in national and international journals.