Neospora caninum: Killing the Survival Artist

The main problem associated with Neospora caninum and the corresponding disease, neosporosis, are abortions in cattle causing serious veterinary health issues and economic losses within livestock production. In the work presented here, the efficacy of toltrazuril, an anti-coccidial drug, was further investigated using two approaches: (I) a mouse model to assess the effect of the drug on congenitally acquired N. caninum-infection in newborn mice and (II) cell culture-based assays to assess treatment duration time for parasitostatic versus parasiticidal activity. Furthermore, the work was directed to establish a novel molecular detection method to clearly distinguish between live and dead parasites. The last part of the thesis work concentrated on the immune response induced by N. caninum. To pursue this, interaction of N. caninum with dendritic cells (DCs) was examined, as nothing is known so far about the invasion ability of N. caninum into DCs and the survival of parasites in these cells.

Autorentext

Maria Strohbusch did her study in Biochemistry at the Friedrich-Schiller Univeristy Jena (Germany) from 2000 to 2005. After her diploma work, she swtiched to the Institute for Parasitology of Vetsuisse- and Medical Faculty Bern (Switzerland)and did her PhD work within the Graduate School for Cellular and Biomedical Sciences in Bern.