Neurodegenerative Diseases

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Covers clinical and genetic aspects, as well as biomarkers for early diagnosis and treatment Translational (from bench to bedside) approach Includes chapters on neurodegeneration in classically non-degenerative disorders

Autorentext

Daniela Galimberti, PhD

Senior Researcher

Alzheimer Center

Neurology Unit

University of Milan

Fondazione Ca' Granda, IRCCS Ospedale Policlinico

Milan, Italy

Daniela Galimberti got her degree in Biological Sciences in 1996 and her PhD in Neurological Sciences in 2004.

She is the Chief of the Laboratory of the Alzheimer Center at the Policlinico University Hospital (Milan, Italy). Her main interests include genetics and bio-molecular aspects of neurodegenerative disorders (Alzheimer's disease, Frontotemporal Lobar Degeneration) and demyelinating diseases (Multiple Sclerosis).

Dr. Galimberti is the Chair of the subcommittee on Dementia of the European Neurological Society.

She is author of 195 scientific articles in international peer-reviewed journals, 10 chapters in international volumes, and more than 250 contributions to conferences. He serves as reviewer for several neurological journals. She is a Senior Associate Editor of the Journal of Alzheimer's disease.

Elio Scarpini, MD

Professor of Neurology

Chief of the Alzheimer Center

Neurology Unit

University of Milan

Fondazione Ca' Granda, IRCCS Ospedale Policlinico

Milan, Italy

Elio Scarpini got his degree in Neurology in 1981 and he is professor of Neurology at the University of Milan. He is the Chief of the Alzheimer Center at the Policlinico University Hospital (Milan, Italy). His main interests include clinical and therapeutic aspects of neurodegenerative disorders (Alzheimer's disease, Frontotemporal Lobar Degeneration) and demyelinating diseases (Multiple Sclerosis).

He is author of more than 250 scientific articles in international peer-reviewed journals, 8 chapters in international volumes, and more than 350 contributions to conferences.

He serves as reviewer for several neurological journals. He is a member of the Editorial Board of the Journal ofNeurology and is an Associate Editor of the Journal of the Neurological Sciences.

Inhalt

Genetics and Epigenetics: Basic Concepts.- Alzheimer's Disease: Clinical Aspects and Treatments.- Autosomal Dominant Alzheimer's Disease: Underlying Causes.- Genetic Risk Factors for Alzheimer's Disease.- The Role of Cerebrovascular Disease in Cognitive Disease.- Non-genetic Risk Factors for Alzheimer's disease.- Frontotemporal Lobar Degeneration: Genetics and Clinical Phenotypes.- Alzheimer's Disease and Frontotemporal Lobar Degeneration: Mouse Models.- Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Frontotemporal Dementia.- Biomarkers for Alzheimer's Disease and Frontotemporal Lobar Degeneration: Imaging.- Amyotrophic Lateral Sclerosis: Genotypes and Phenotypes.- Uncommon Dementias.- Neurodevelopment Alterations, Neurodegeneration and Immunoinflammatory Patterns in the Pathophysiology of Schizophrenia.- Neurodegeneration and Multiple Sclerosis.