Neuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management.

This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics.

Autorentext
320 papers and has an h-index of 73 (Google Scholar).

Klappentext

Advances in Computers, the latest volume in the series published since 1960, presents detailed coverage of innovations in computer hardware, software, theory, design, and applications. In addition, it provides contributors with a medium in which they can explore their subjects in greater depth and breadth than journal articles usually allow. As a result, many articles have become standard references that continue to be of significant, lasting value in this rapidly expanding field.

Inhalt

1. Introduction
2. Neural regeneration as a disease modifying therapeutic strategy for Alzheimer's disease
3. Animal models
4. Mechanisms of Neuronal Microtubule Loss in Alzheimer's Disease
5. Tau-centric therapies for treating Alzheimer's Disease
6. The potential of small molecules in preventing tau oligomers formation and toxicity
7. A novel neuroprotection target with distinct regulation in stroke and Alzheimer´s disease
8. Sirtuin modulation as novel neuroprotective strategy for Alzheimer's Disease
9. Rescue of neurons by resolving inflammation
10. Targeting transition metals for neuroprotection in Alzheimer's disease
11. Multifunctional effect of human serum albumin towards neuroprotection in Alzheimer disease
12. RGS2 and SIRT1 link renin angiotensin aldosterone system to Alzheimer's disease
13. Neuroprotective drug development: the story of ADNP, NAP (davunetide) and SKIP