Neuroreceptor Endocytosis and Signaling in Health and Disease

This book covers a wide range of neuroreceptor topics, including receptor endocytosis and signaling and the role of neuroreceptors in health and disease conditions. It focuses on various important nervous system receptors and their biomedical applications, especially receptor signaling. The book provides a look into the current developments of various neuroreceptors responsible for pathophysiological conditions. It is a valuable, cutting-edge, in-depth reference on neuroreceptors, featuring clearly written chapters from major contributors in the field. The central aim is to aid future investigators, researchers, students, and stakeholders to perform their research with greater ease. This book provides an excellent basis from which scientific knowledge can grow, widen, and accelerate receptor biology tools toward biomedical applications.

Provides insights into the neuroreceptor endocytosis and signaling and the cutting-edge techniques used for their study Presents the latest in vitro and in vivo research findings on the role of neuroreceptors in disease conditions Provides coverage of several neuroreceptors, illustrating the mechanistic pathway of signaling

Autorentext

Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry (2010) from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, Louisiana, USA. He has worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 13 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published more than 50 research articles in peer reviewed journals, 58 book chapters and 8 books. He received the MBSI (Microbiologist Society, India) Senior Teacher award-2024 and Agathiyar Chemical Biology award-2024 from the Society of Chemical and Synthetic Biology, India. He has presented several papers in the different national and international conferences. He has extensive experience in microbial characterization, molecular genetics, cell culture, fluorescence/confocal microscopy, and in silico analysis. He is a life member of the Association of Microbiologists of India (AMI), the Microbiologists Society, India (MBSI), the Society for Chemical & Synthetic Biology (SCSB). the Indian Science Congress Association (ISCA), Indian Network for Soil Contamination Research (INSCR), and Aquatic Biodiversity and Conservation Society (ABCS), India. He serves as an editorial board member, reviewer of peer-reviewed journals and a member of national and international societies. He is also a member of the extended IQAC team, at Gargi College, University of Delhi.

Inhalt

Insights of neuroreceptor endocytosis and signaling in health and disease.- Signaling Molecules: Importance in Health & Disease Conditions.- Emerging concept of receptor endocytosis and signalling.- Cutting-Edge Techniques Unveiling Receptor Endocytosis and Signaling Dynamics.- 1-Adrenergic receptor endocytosis and signalling.- 2-Adrenergic receptor endocytosis and signalling.- Muscarinic receptor-mediated adrenaline secretion in adrenal medullary chromaffin cells and roles of adrenaline for health and disease.- Activation mechanisms, trafficking, and signalling of GABAA receptors.- Kainate receptors trafficking, signalling and functional roles.- Glycine receptor endocytosis and signalling.- Histamine receptors endocytosis and signalling.- Opioid receptor endocytosis and signalling.- P2Y Receptor Endocytosis and Signalling.- Transferrin receptor endocytosis and signalling in health and disease.- Neurokinin 1 Receptor Endocytosis and Signaling.- Axon guidance receptor endocytosis, trafficking and signaling in health and disease.- Vesicular trafficking in neuronal development.- The cellular prion protein as universal receptor for amyloid proteins.- Drug Delivery to the Brain Using Endocytic Receptors as Carriers.- Application of Bioinformatics in Receptor Biology and Drug Discovery.