Neutron Capture Therapy

This book offers a detailed review of progress in Neutron Capture Therapy (NCT), covering neutron sources, boron chemistry, drugs for NCT, dosimetry and radiation biology and discussing the use of NCT to treat many malignancies and some non-malignant diseases.

Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

State of the art report on neutron capture therapy Summarizes the progress made in recent decades Multidisciplinary approach Written by the most experienced specialists Includes supplementary material: sn.pub/extras Includes supplementary material: sn.pub/extras

Inhalt
Part I: Neutron sources: Fission Reactor Based Irradiation Facilities for Neutron Capture Therapy.- Accelerator-Based BNCT.- Compact Neutron Generator for BNCT.- Californium-252 as a neutron source for BNCT.- Part II: Boron: Boron Chemistry.- New Candidates for Boron Carriers in BNCT.- Drugs for BNCT (BSH and BPA).- Part III: Analysis and Imaging: Boron analysis and Boron Imaging.- Proteomic investigations for Boron Neutron Capture Therapy.- Analysis and Imaging: PET.- Localized quantitative detection and imaging of Boron by Magnetic Resonance.- Part IV: Physics: Boron Neutron Capture Therapy: Application of Radiobiological Principles.- Tolerance of Healthy Tissues and Ideal Radiation Dose on BNCT.- Part VI: Clinical Applications: Clinical trials in BNCT a challenging task.- External beam BNCT for Glioblastoma mulitforme.- Clinical results of sodium borocaptate (BSH)-based intra-operative boron neutron capture therapy (IO-BNCT).- Boron neutron capture therapy for malignant meningiomas.- Feasibility for intramedullary spinal glioma.- BNCT for Advanced or Recurrent Head and Neck Cancer.- Studies on the possible application of BNCT to thyroid cancer.- Malignant Melanoma.- Application of Neutron Capture Therapy for Local Recurrenced Breast Cancer.- Recurrent breast cancers & inflammatory breast cancers.- Liver Metastases.- Boron Neutron Capture Therapy for Children with Malignant Brain Tumors.- Part VII: Non malignant diseases: Prevention of vascular restenosis after vascular angioplasty.-Boron Neutron Capture Synovectomy.- Managerial Aspects of BNCT at a nuclear research reactor.