New factors in the differentiation of dopaminergic neurons

In the mammalian brain, the dopaminergic circuits (nigrostriatal and meso-cortico-limbic pathways) are essential for motor control, reward mechanisms and modulation of affective and emotional states. Dysfunctions of these circuits are involved in serious neurological and psychiatric diseases (Parkinson's disease, schizophrenia, ADHD and addiction). For these reasons, the study of molecular mechanisms involved in the acquisition and maturation of midbrain-dopaminergic neurons is essential to generate in vitro DA neurons useful for disease modelling and regenerative medicine. The present work, by identifying microRNAs involved in DA development, contributes to add new and interesting information on the molecular mechanisms underlying the DA differentiation and maintenance, leading to the identification of new molecular targets for potential therapeutic strategies to cure pathological disorders affecting the DA system.

Autorentext

Dr. Pulcrano was born in Naples on January 9, 1988. He realizes his curiosity for biological world during the days spent in the Vesuvio's countrysides, stimulated from father's rudiments in anatomy and medicine. At the age of 28 he reached a PhD in neurosciences at the University of Naples Federico II studing the dopaminergic system.