New Insights on the Development of the Vascular System

New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years.

Although scientific literature covers the descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis give new insight into the mechanisms by which vessels form and regress and how blood flow changes directions in the same vessels.

Autorentext

Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times.

He has published many books with both Elsevier and Springe

Klappentext

New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years.

Although scientific literature covers the descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis give new insight into the mechanisms by which vessels form and regress and how blood flow changes directions in the same vessels.

Inhalt

1. Introduction
   
   2. Vasculogenesis
   3. Angiogenesis
   4. Nonsprouting angiogenesis: Intussusceptive microvascular growth
   5. Endothelial tip, stalk, and phalanx cells
   6. Role of neuropilins
   7. Role of notch and notch ligands
   8. Semaphorins and netrin-UNC5B signaling
   9. Lumen formation and perfusion
   10. Network formation
   11. Remodeling
   12. Pruning
   13. Maturation and stabilization and pericyte recruitment
   14. Arteriogenesis
   15. Arterial and venous specification
   16. Role of oxygen
   17. Epigenetic regulation of vascular development (microRNAs)
   18. Angiogenesis and organogenesis
   19. Concluding remarks