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Nicastrin
CHF 161.95
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GT2JDEQA4I5
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Geliefert zwischen Mo., 04.05.2026 und Di., 05.05.2026
Details
High Quality Content by WIKIPEDIA articles! Nicastrin (abbreviated NCT) is a protein that is part of the gamma secretase protein complex, which is one of the proteases involved in processing amyloid precursor protein (APP) to the short Alzheimer's disease-associated peptide amyloid beta. The other proteins in the complex are presenilin, which is the catalytically active component of the complex, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer 2). Nicastrin itself is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the complex, all of which undergo significant post-translational modification before becoming active in the cell. Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.
Weitere Informationen
- Allgemeine Informationen
- GTIN 09786131080616
- Editor Lambert M. Surhone, Miriam T. Timpledon, Susan F. Marseken
- EAN 9786131080616
- Format Fachbuch
- Titel Nicastrin
- Herausgeber Betascript Publishing
- Anzahl Seiten 112
- Genre Biologie
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