Nitric oxide in diabetes and hypertension

Nitric oxide is one the pivotal molecule released by endothelium and its turnover is vital for proper endothelial function. Various chronic risk factors associated with Type II Diabetes Mellitus and hypertension may disrupt the homeostatic balance in vascular system potentiating endothelial dysfunction. Endothelial dysfunction accompanies all cardiovascular risk factors and presumably plays a prime role in the occurrence of cardiovascular events associated with diabetes and hypertension. Although, it is apparent that NO turnover has a deep influence on the etiology of diabetes and hypertension, much remains to be done to substantiate NO-targeted therapies for the treatment of these disorders. Likewise, a systematic detail of ascertaining the relationship of NO dynamics with such disorders need to be elucidated before NO-targeted therapeutic proposition is considered. Our study is an attempt to quantitate and compare the NO level status in these different pathological conditions and analyse it in relation to the effect of disease.

Autorentext

PhD, M.Phil., MSc (Biotechnology).Currently, working as a Principal Investigator of project sanctioned under "Young Scientist Scheme" by DST, New Delhi.Qualified various prestigious fellowships "CSIR-NET & GATE" and authored various national and international publications.