NMR Spectroscopy in Pharmaceutical Analysis

Klappentext The book aims to explain the fundamental of quantitative NMR spectrsocopy on the one hand and to demonstrate the power of the method on the other. Thus! it can be used as textbook for advanced students (master and PhD students) and researchers. However! experts in analytical departments of the pharmaceutical companies will be addressed to learn the method beside the application of HPLC! GC and CE. Even experts in NMR spectroscopy which are normally dealing with the structure elucidation of synthesis products and/or natural products will find valuable information because the field of quantitative NMR spectroscopy has largely developed for the last ten years. Zusammenfassung Aims to describe the possibilities of qNMR in pharmaceutical analysis. This work offers an introduction to the physical fundamentals and techniques. It describes the principles of the application in drug analysis: quality evaluation of drugs! polymer characterization! natural products and corresponding reference compounds and drug formulations.

Zusammenfassung
Aims to describe the possibilities of qNMR in pharmaceutical analysis. This work offers an introduction to the physical fundamentals and techniques. It describes the principles of the application in drug analysis: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds and drug formulations.

Inhalt
Part I: Fundamentals and Techniques. 1. NMR Spectroscopy in drug analysis; application in international pharmacopoieae and related analyses. (U. Holzgrabe, B. Waibel, C. Schollmayer). 2. Principles in NMR spectroscopy. (B. Diehl). 3. qNMR in solid state NMR. (I. Wawer). 4. qNMR. (F. Malz) 5. Internal standards for quantification and pattern recognition, e.g. ERETIC; and principal component analysis of mixtures, e.g. beverages (AmixT). (M. Spraul, E. Humpfer). 6. Microcoil NMR spectroscopy/Nanoliter-Volume NMR spectroscopy. (A.G. Webb). Part II: General Applications 7. NMR spectroscopy in impurity profiling including aspects of pharmacopoeia. (U. Holzgrabe). 8. NMR spectroscopy of pharmaceutical polymers. (B. Diehl). 9. Natural Products analysis by qNMR. (B. Diehl). 10. Solid-state measurements of drugs and drug formulations. (I. Wawer) Part III Special Applications. 11. NMR assays for identity of polysaccharides from bacteria used in vaccine manufacture. (C. Jones, N. Ravenscroft). 12. Metabolic profiling. (C.K. Larive). 13. Fluorine-19 and phosphorus-31 NMR for quantitation of fluorinated and phosphorylated drugs and their metabolites in biofluids. (M. Malet-Martino). 14. Solid-state measurements of bones. (C. Jäger). 15. qNMR for assessing the purity of agrochemicals (R.J. Wells). 16. Assessment of inhibitory potency of antibiotics by MRI (C. Faber). 17. Quantitation 2D NMR analysis of glycosaminoglycans. (G. Torri). 18. DOSY NMR for Drug Analysis. (M. Malet-Martino, et al). 19. NMR spectroscopy of peptides as an alternative to AAA. (E. Kellenbach, K. Sanders, P.L.A. Overbeeke). 20. The Hypernation of NMR and Other Spectroscopies in Drug and Natural Products Research. (I.D. Wilson). 21. Online-NMR-Spektroscopy. (H. Hasse)