Notch Signaling in Embryology and Cancer

This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch's role in the development of the embryo to the Notch signaling pathway's role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch's role in senescence, the regulation of Notch signaling by microRNAs, Notch's role in the microbiome, diet and its influence on Notch signaling and more.

Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

The content is presented in a logical and coherent structure, enabling the reader to readily access relevant information The volume editors are renowned experts on Notch and Notch Signaling and the chapter contributors are all internationally-recognized researchers Timely and urgently needed update in a rapidly moving field

Autorentext

Jörg Reichrath is Professor for Dermatology and Deputy Director of the Clinic for Dermatology, Allergology and Venerology at the Saarland University Medical Center in Homburg, Germany. Reichrath has received his academic degrees (Dr. med.) from the Saarland University, Germany. His research interests include photobiology, dermato-endocrinology and dermato-oncology. He is a member of numerous national and international scientific organizations, including the German Dermatological Society (DDG), the Deutsche Krebsgesellschaft (DKG), the German Dermatologic Cooperative Oncology Group (DeCOG), the Arbeitsgemeinschaft Dermatologische Forschung (ADF) and the Deutsche Akademie für Photobiologie und Phototechnologie e. V. (DAFP). He has been awarded numerous prices including the Arnold-Rikli-price.

Sandra Reichrath is researcher and scientist at the Clinic for Dermatology, Allergology and Venerology at the Saarland University Medical Center Hospital in Homberg, Germany, where she at present works at the School of Health Professions. She received her academic degrees from the Faculty of Biology of the Albert-Ludwig-University, Freiburg, Germany. Her research interests include Notch signaling in glioblastoma and skin tumors.

Inhalt

Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword.- Transcription factor RBPJ as a molecular switch in regulating the Notch response.- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer.- Notch and endometrial cancer.- Notch and Esophageal Squamous Cell Carcinoma.- Notch signaling and liver cancer.- Notch inHead and Neck Cancer.- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis.- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond.- Notch Signaling in Thyroid Cancer.- The Relevance of Notch Signaling in Cancer Progression.- Notch Signaling and the Breast Cancer Microenvironment.- Notch pathway: a journey from notching phenotypes to cancer immunotherapy.- Index. <p