Novel Angiogenic Mechanisms

New experimental observations often require fresh concepts for their interpretation, and at times even changes of paradigms. This is the situation with the recent realization that circulating endothelial progenitor cells may have an important contribution to the maintenance and formation of new endothelium in adult organisms, in a surprisingly wide variety of situations. The classical paradigm of angiogenesis, centered on the notion of "sprouting" can hardly accommodate them. It was previously realized that it needs to be "stretched out" to include alternative mechanisms of microvascular development, such as intussusception and capillary fusion. However, a major debate where to reconsider the sprouting mechanism, and to promote alternative views, did not take place yet. The number of publications in this field increased exponentially in the last years. Nevertheless, the concepts and notions so much needed to describe and to explain the new observations are still scarce, and heterogeneous. Within the larger community dedicated to the study of angiogenesis, the researchers involved in investigation of circulating precursor endothelial cells biology represent a subgroup with specific preoccupations and opinions. Many of them did not meet each other so far, and no major scientific events have been dedicated before exclusively to their interests. For the above reasons, the idea to organize a symposium addressing the new developments in angiogenesis research was received with enthusiasm by all those involved in its preparation.

Klappentext

This volume illustrates the current lines of investigation of the angiogenic mechanisms based on contribution of circulating progenitor cells. The main themes that currently dominate this research field are: the origin of these cells, their tissue engraftment, their phenotypic modulation leading to the transformation into endothelial cells, etc. This volume is a key reference for angiogenesis researchers and students alike, in the fields of cardiovascular medicine, neoplastic disorders, wound management and tissue engineering, among others. BRKey Features: P-Fresh data and concepts are presented to advance our understanding of basic angiogenic mechanisms. BR- Focuses entirely on an emerging paradigm able to supplement the old angiogenic mechanism, called the "sprouting" model, in accounting for all real-life situations. BR- Deals with the potential of progenitor cells to contribute to the maintenance and/or regeneration of tissues in an adult organism. /P

Inhalt

1. Current Priorities in the Research of Circulating Pre-Endothelial Cells.- 2. In Vivo and In Vitro Properties of CD34+ and CD14+ Endothelial Cell Precursors.- 3. Evidence From A Leukemia Model For Maintenance Of Vascular Endothelium By Bone-Marrow-Derived Endothelial Cells.- 4. Cross Talk Between Haematopoiesis and Angiogenesis.- 5. The Contribution of Adult Hematopoietic Stem Cells to Retinal Neovascularization.- 6. In Vitro Transformation of Monocytes and Dendritic Cells Into Endothelial Like Cells.- 7. Phenotypic Overlap Between Monocytes and Vascular Endothelial Cells.- 8. Dissection of Monocyte and Endothelial Activities By Using Vegf-Receptor Specific Ligands.- 9. Circulating Endothelial Cells as a Novel Marker of Angiogenesis.- 10. Tissular Insemination of Progenitor Endothelial Cells: The Problem, and A Suggested Solution.