Novel Molecular Approaches to Anti-Inflammatory Therapy

In July 1994, the Canadian Inflammation Society in Toronto hosted a symposium entitled "Novel molecular approaches to anti-inflammatory therapy" as a satellite of the xnth International Congress of Pharmacology. For several reasons the above topic was singled out and separated from the general Congress. Major advances have recently been made in the understanding of inflammatory mechanisms. These advances serve as the basis for a new generation of therapeutic agents which may potentially alter our approach to inflammatory processes and infectious diseases. The Satellite Symposium focused on recent advances in diversified fields including arachidonate metabolites, actions of cytokines, chemokines, cellular adhesion molecules and novel molecular approaches in the therapy of inflammation. Scholarly addresses were presented by eminent experts in their respective fields. In this book are included 17 papers which describe in detail novel approaches to the study of inflammation. We hope that this book will serve not only as a summary of present knowledge, but will stimulate both scientists and clinicians to continue their efforts to battle inflammatory diseases. W. Pruzanski, Chair, Publications Committee P. Vadas, Chair, Organizing Committee 1 AAS46 Novel Molecular Approaches to Anti-Inflammatory Theory © 1995 Birkhauser Verlag Basel EOSINOPHIL CHEMOATIRACTANIS GENERATED IN VIYO T. I. Williams, D. A. Griffiths-Iohnson, P. I. lose and P. D. Collins. Department of Applied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, United Kingdom.

Inhalt
Eosinophil chemoattractants generated in vivo.- Chemokines and their role in human disease.- Structure/function analysis of human interleukin 5 and its receptor.- Potential phospholipase A2s involved in inflammatory diseases.- Mediation of inflammation by cyclooxygenase-2.- Secretory phospholipase A2 inhibitors. Possible new anti-inflammatory agents.- Recent insights into the structure, function and biology of cPLA2.- Control of inflammatory processes by cell-impermeable inhibitors of phospholipase A2.- Leukocyte adhesion and the anti-inflammatory effects of leukocyte integrin blockade.- ANTI-ICAM in inflammatory disease.- Complementary peptides as recognition molecules.- Nitric oxide-releasing NSAIDs: A novel class of GI-sparing anti-inflammatory drugs.- Anti-inflammatory lipocortin-derived peptides.- Inhibition of lipid mediator biosynthesis in human inflammatory cells by BIRM 270.- The use of anti-PECAM reagents in the control of inflammation.- Selective inhibitors of COX-2.- New frontiers in the pharmacotherapy of inflammation.