Nuclear Hormone Receptors in Skin

Nuclear hormone receptors (NHR) act as transcription factors by directly binding to DNA and initiating the transcription of genes. They play an important role in tissue homeostasis by modulating critical cell functions such as metabolism, proliferation, differentiation, cell death and inflammation.This study was designed to determine patterns of NHR expression in skin under physiologic and pathologic conditions. The results reveal a specific expression pattern in normal skin as well as disease specific expression patterns for psoriasis and atopic dermatitis. While the increase in PPAR in psoriatic skin has been independently replicated, the significance of the changes in other NHRs requires independent confirmation.In conclusion, these expression patterns may reflect transcriptional NHR circuits in skin that are amenable to therapeutic targeting, and the knowledge of specific NHR patterns in diseased skin might be useful in the diagnosis of cases with an uncertain clinical phenotype.

Autorentext

Claudia Angela Granbichler Born on June 25 1983 in Vienna, AT 2001 Graduation from the wirtschaftskundlichen Bundesrealgymnasium in Salzburg, Austria 2007 Graduation from Innsbruck Medical University, AT Currently working at the Department of Neurology at the University Hospital of Innsbruck and part of the PhD programm in neurosciences