Ocular Pharmacology and Toxicology

Covering ocular pharmacokinetics, pharmacodynamics, and toxicology, Ocular Pharmacology and Toxicology provides ophthalmologists, toxicologists, and pharmacologists with both an introduction to the proper methods for ocular pharmacology and toxicology as well as providing practical methodologies for conducting ocular studies. Expert authors have contributed detailed chapters on study design, analysis, and routes to regulatory approval for various types and routes of ophthalmic drugs. As a volume in the Methods in Pharmacology and Toxicology series, chapters feature the kind of in-depth specifics and implementation advice to ensure successful results.

Practical and authoritative, Ocular Pharmacology and Toxicology serves as an ideal basis of training in the proper design and conduct of essential studies to accurately determine pharmacokinetics and ocular toxicity from the systemic, topical, periocular, or intraocular administration of drugs or compounds, from the use of ocular medical devices and from ocular surgical procedures.

Serves as an ideal training manual for exploring design and conduct of ocular pharmacology and toxicology studies Features practical methodologies that are tested and successful Includes study design, analysis, and routes to regulatory approval for a variety of ophthalmic drugs

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Challenges in Ocular Pharmacokinetics, Pharmacodynamics, and Toxicology.- Selection of Appropriate Animal Models in Ocular Research: Ocular Anatomy and Physiology of Common Animal Models.- Challenges and Strategies in Drug Residue Measurement (Bioanalysis) of Ocular Tissues.- Chemistry, Manufacturing, and Control of Ophthalmic Formulations.- ADME and Ocular Therapeutics: Retina.- Compositions, Formulation, Pharmacology, Pharmacokinetics, and Toxicity of Topical, Periocular, and Intravitreal Ophthalmic Drugs.- Sustained-Release Ocular Drug Delivery Systems: Bench to Bedside Development.- The Ophthalmic Examination as It Pertains to General Ocular Toxicology: Basic and Advanced Techniques and Species-Associated Findings.- Study Design and Methodologies for Evaluation of Anti-Glaucoma Drugs.- Study Design and Methodologies for Study of Ocular Medical Devices.- Methodologies for Microscopic Characterization of Ocular Toxicity.- Nanoparticles for Drug and Gene Delivery in Treating Diseases of the Eye.