Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors: Volume 115

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

Autorentext
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

Klappentext

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

Zusammenfassung
Reflects on developments and research surrounding G protein-coupled receptors. This title includes chapters that cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Inhalt

1. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors*Michael T. Klein, Paige N. Vinson and Colleen M. Niswender

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2. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders*Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender

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3. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery*Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis

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4. G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design*Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri

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5. GPCRs in Stem Cell Function*Van A. Doze and Dianne M. Perez

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6. Application of Receptor Theory to Allosteric Modulation of Receptors*David A. Hall

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7. What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors*Frederick J. Ehlert

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8. Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors*Jesús Giraldo

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9. Chemokine Receptor Oligomerization and Allostery*Bryan Stephens and Tracy M. Handel

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10. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators*Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac*