Organofluorine Compounds in Biology and Medicine

Informationen zum Autor Dr. Prakash Reddy is currently active in research and teaching at the Missouri University of Science and Technology. He has received his Ph.D. in organic chemistry from the Case Western Reserve University, Cleveland, Ohio, and M.Phil. from the University of Hyderabad, India. He was an Adjunct and Visiting Professor at nationally reputed universities prior to joining Missouri University of Science and Technology in 2000. He received the Golden Key National Honor Society award for teaching excellence at Case Western Reserve University, and was a NASA Faculty Fellow at Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA. He has research interests in synthetic, mechanistic, and biological organic chemistry, and has significantly contributed to the area of carbocations and electrophilic reactions, superacids, and organofluorine chemistry. This book covers topics on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

Autorentext
Dr. Prakash Reddy is currently active in research and teaching at the Missouri University of Science and Technology. He has received his Ph.D. in organic chemistry from the Case Western Reserve University, Cleveland, Ohio, and M.Phil. from the University of Hyderabad, India. He was an Adjunct and Visiting Professor at nationally reputed universities prior to joining Missouri University of Science and Technology in 2000. He received the Golden Key National Honor Society award for teaching excellence at Case Western Reserve University, and was a NASA Faculty Fellow at Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA. He has research interests in synthetic, mechanistic, and biological organic chemistry, and has significantly contributed to the area of carbocations and electrophilic reactions, superacids, and organofluorine chemistry.

Klappentext

This book covers topics on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

Inhalt

1. Introduction: General aspects of organofluorine compounds2. C-F bond strengths3. Effect of the neighboring C-F bonds on the C-H bond dissociation energies4. Effect of fluorine on the acidity and basicity5. Effect of fluorine on the metabolic stability6. Effect of fluorine on the bioavailability7. Positron emission tomography (PET) tracers8. 19F NMR Spectroscopic techniques for probing biochemical mechanisms9. Summary and outlook