Osteosarcopenia

Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity.

Autorentext
Professor Gustavo Duque is a world leader in ageing and musculoskeletal research. He is a geriatrician, clinical, and biomedical researcher with special interest in the mechanisms and treatment of osteoporosis, sarcopenia, and frailty in older persons. His initial training included Internal Medicine at Javeriana University (Colombia) and Geriatric Medicine, completed at McGill University in Montreal, Canada. He obtained his PhD at McGill with a thesis entitled Molecular Changes of the Aging Osteoblast.” He moved to Australia to join the faculty as Associate Professor and Head of the Division of Geriatric Medicine and Director of the Musculoskeletal Ageing Research Program at Sydney Medical School Nepean. In 2015, he moved to Melbourne for a new position as Chair of Medicine and Director of the Australian Institute for Musculoskeletal Science at the University of Melbourne. His major research interests include the elucidation of the mechanisms of age-related bone loss, osteoporosis, sarcopenia and frailty. Bruce R. Troen, MD, is a physician-scientist formally trained in geriatrics and molecular biology. Dr. Troen is a professor and chief of the Division of Geriatrics and Palliative Medicine in the Department of Medicine within the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, a physician-investigator with the WNY VA Healthcare System, and Chief of Geriatric Services at the Erie County Medical Center. A thought leader in aging-related geroscience and molecular biology and regional leader in geriatric care, Dr. Troen founded and directs the Center of Excellence for Alzheimer's Disease of Western New York and the Center for Successful Aging at the University at Buffalo.

Inhalt

1. Muscle and bone biology - Similarities and differences
   
   2. Mesenchymal stem cells as regulators of bone, muscle and fat formation
   3. Age-related changes in muscle, fat and bone: Their impact on metabolism and function.
   4. Cross-talk between muscle, fat and bone
   5. Falls and fracture risk assessment - The role of osteoporosis, obesity and sarcopenia.
   6. Good and bad fat in osteosarcopenia
   7. Glucose metabolism and osteosarcopenia
   8. Diagnosis of osteosarcopenia - Clinical
   9. Diagnosis of osteosarcopenia - Imaging
   10. Genetics of osteosarcopenia
   11. Non-pharmacological interventions for osteosarcopenia
   12. Pharmacological treatments of osteosarcopenia
   13. Social impact of osteosarcopenia
   14. Models of care for falls and fracture prevention