Pathogenesis of Leishmaniasis

This book details the latest research into leishmaniasis. It also addresses how advances in understanding can be applied to prevention, control and treatment of what the WHO has classified a neglected tropical disease.

This book discusses recent developments in several laboratories studying leishmaniasis. Sequencing of the human genome, as well as of the leishmania genome, has led to significant advances in our understanding of host-immune responses against leishmania, and mechanisms of infection-induced pathology, which is responsible for morbidity and mortality. Pathogenesis of Leishmaniasis focuses on the latest basic research into leishmaniasis, but also addresses how advances in understanding can be applied to prevention, control and treatment of what the WHO has classified a neglected tropical disease.

Will address the most recent developments in the understanding of leishmaniasis Uses information gained from the sequencing of the leishmania genome to assess the host-immune response Focus is primarily on the most recent basic research, but will also consider how to apply the knowledge gained to prevention, control and treatment of this neglected tropical disease Includes supplementary material: sn.pub/extras

Inhalt
Mechanisms of immunopathology of leishmaniasis.- Update on Leishmania mediators that promote immune evasion.- Paratransgenic Control of Leishmaniasis: New Developments.- *Current status and future challenges for the development of Genetically Altered Live Attenuated Leishmania* vaccines.- Reservoir control strategies for Leishmaniasis: past, present and future.- Treatment modalities for cutaneous and visceral leishmaniasis.