Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

With contributions from an interdisciplinary team of recognized experts, this illustrated volume reviews the diverse mechanisms-genetic, metabolic, and molecular-that give M. tuberculosis its antibiotic-resistant virulence and allow it to evade immune systems.

Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host's innate immune defence mechanisms.

In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

A stimulus for the further exploration of the intricate biology of Mycobacterium tuberculosis and its interaction with the host Written by respected experts from different disciplines Richly illustrated Includes supplementary material: sn.pub/extras

Klappentext

Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Inhalt

Genetic Diversity in Mycobacterium tuberculosis.- DNA Metabolism in Mycobacterial Pathogenesis.- Molecular Biology of Drug Resistance in Mycobacterium tuberculosis.- Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations.- Getting Across the Cell Envelope: Mycobacterial Protein Secretion.- A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria.- Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes.- Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis.- Host-Pathogen Interactions During Mycobacterium tuberculosis Infections.