Pathology of Graft vs. Host Disease

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, pathologists and researchers with an interest in GVHD and its mimickers. The book reviews new data about risk factors affecting outcomes, pathologic features, and profiles the new WHO guidelines as well as current practices. The richly illustrated text covers the gamut of gross and histologic presentations of acute GVHD in skin, gut, liver, and additional organs affected by chronic GVHD. An engaging aspect of this book is the format of patient based cases as the focus for the major chapters teaching points. The case presentations include both infectious and toxic complications that mimic GVHD, or displaying similar morphologies. Recent up to date references on clinical investigations and pathogenesis make the reading and teaching resonant with the readers.

Pathology of Graft vs. Host Disease will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging disease. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters were written by experienced transplant physicians with expertise in their fields.

Richly illustrated with comparative gross and histologic pictures of GVHD. Provides a case based teaching primer. Written by experts in their fields.

Autorentext

Cecilia CS YeungFred Hutchinson Cancer Research CenterUniversity of WashingtonSeattle, WAUSA
Howard M. ShulmanSeattle Cancer Care AllianceSeattle, WAUSA

Klappentext
GVHD is the major cause of non-relapse morbidity and mortality after hemopoietic cell transplantation. This text provides a comprehensive, state-of-the art review of the pathology of GVHD for clinicians, pathologists and researchers with an interest in GVHD. The book covers the histologic spectrum of GVHD, clinicopathologic features, pathobiology, grading, risk factors affecting outcome, and differential diagnosis. It profiles the new NIH consensus and international guidelines for diagnosing GVHD. The text chapters are based on actual patient cases covering the gamut of acute and chronic GVHD and associated complications. The discussion initiated teaching points and key histologic points make the reading and teaching more interactive while providing a stimulating discussion of difficult differentials. The chapters are richly illustrated with colored comparative gross and histologic images and include extensive references by experts in the fields including the most up-to-date scientific and clinical information. Pathology of Graft vs. Host Defense: A Case Based Teaching Guide serves as a useful resource for physicians and researchers interested in this challenging disease. It also provides a concise yet comprehensive summary of the current status of the field that helps guide patient management and stimulates investigative efforts.

Inhalt
The Contributions of Pathology to the Diagnosis and Management of GVHD - Caveats and Lessons Learned.- Evolutions in the Clinical Management of GVHD.- Early GVHD with Follicular Rash.- The Basic Sequence of Injury in Acute Skin GVHD.- Leukemia Cutis and Hematologic Malignancies with Cutaneous Manifestation.- Lichenoid Inflammatory Phase of Chronic Skin GVHD.- Cutaneous Chronic GVHD: Sclerodermatous and Morpheic Variants.- Early Changes of Gut GVHD; Criteria for Crypt Cell Apoptosis and the Differential Diagnosis.- Persistent Gastrointestinal GVHD: The Application and Utility of Histologic Grading Schemes.- Chronic, Persistent, and Fatal Gastrointestinal GVHD.- Abdominal Pain and Diarrhea When it is Not GVHD.- Mucosal Chronic GVHD Affecting the Oral Pharyngeal, Esophageal, and Anogenital Regions.- Pre-Transplant Liver Disorders: Post-Transplant Impact on Developing Venocclusive Disease/Sinusoidal Occlusive Disease and Other Hepatic Problems.- The Pathological Spectrum of Hepatic GVHD.-Rapidly Progressing Cholestatic Liver Failure after Allogeneic Stem Cell Transplant from Hepatitis C Positive Donor (FCHCV).- Acute Hepatitic Onset of Liver GVHD Occurring 9 Months Post-Transplant.- GVHD Manifesting as Sicca Syndrome.- Non-Infectious Pulmonary Manifestation of GVHD: Bronchiolitis Obliterans Syndrome.- Kidney Involvement in GVHD.- Manifestations of Chronic GVHD in Other Organ Systems.