Patient-Specific Controller for an Implantable Artificial Pancreas

The thesis focuses on the control of blood glucose devices and design of implantable devices, and offers valuable insights on diabetes mellitus and related physiology and treatments. Diabetes mellitus is a widespread chronic disease in the modern world that affects millions of people around the globe. In Singapore, one in ten of the population has diabetes, and the severity of the problem has prompted the country's prime minister to talk about the disease at the National Day Rally in 2017.

Designing an artificial pancreas that can provide effective blood glucose control for individuals with diabetes is one of the most challenging engineering problems. The author reports on research into the development of an implantable artificial pancreas that can regulate blood glucose levels by delivering appropriate dosages of insulin when necessary.
By sensing blood glucose and injecting insulin directly into the vein, the implantable device aimsto remove delays that occur with subcutaneous blood glucose sensing and insulin delivery. Preliminary in-vitro and in-vivo experimental results suggest that the implantable device for blood glucose control could be a clinically viable alternative to pancreas transplant.

Nominated as an outstanding Ph.D thesis by National University of Singapore, Singapore, Singapore Discusses the development of an implantable artificial pancreas that can regulate blood glucose levels by delivering appropriate dosage of insulin when necessary Outlines the challenging engineering problem of designing an artificial pancreas that can effectively control blood glucose levels Offers valuable insights into in the modeling and control of blood glucose levels and the design of implantable devices

Autorentext

Yvonne Ho received her B.Eng. (Hons) in mechanical engineering from the National University of Singapore in 2002. She spent 8 years as an R&D Engineer in Hewlett-Packard working on print-head reliability and writing systems for business ink printers, during which she worked part-time on an M.Sc. (2010)(NUS). She obtained her Ph.D. from National University of Singapore in 2016, under supervision of Assoc. Prof Chui Chee-Kong. During this time, she was also involved in several research projects. She is currently a Research Staff in Republic Polytechnic, Singapore, working on a funded project. Her interests include control, automation and robotics.

Inhalt

Introduction.- Glucose Metabolism and Diabetes.- Literature Review.- Design of an Implantable Artificial Pancreas.- Model Predictive Controller using Interior Point and AntAlgorithm.- In Vivo Experiment of the Implantable Artificial Pancreas.- Parameter Estimation for Nonlinear Mathematical Model.- Conclusion and Future Work.