Peninsular India and Human Evolution

The mutations are seen in the general homo sapien population of Kerala are the SLOS mutation involving 7DHCR, pyruvate dehydrogenase mutation, CoQ mutation, branched chain ketoacid dehydrogenase mutation, hyper homocysteinemia, Hartnup's disease and porphyria. The mutations are induced by RNA viroids secreted by the archaea. The archaeal RNA viroids get converted to DNA viroids by HERV reverse transcriptase and are integrated by HERV integrase as non-coding sequences in the Neanderthal genome. Induction of the SLOS mutation leads to decreased cholesterol synthesis. Cholesterol oxidation is required for archaeal energetics. The SLOS mutation producing autism results in decreased cholesterol synthesis and decreased substrates for archaeal energetics. The PDH mutation leads to increased generation of ammonia from pyruvate. The endosymbiotic archaea are also ammonia oxidizing and this serves as an inefficient pathway for energetics. Defective archaeal energetics leads to decreased density of endosymbiotic archaea and eventual extinction of the symbiotic homo neanderthalic species. Homo neanderthalic species with reduced endosymbiotic archaeal density becomes the homo sapien species.

Autorentext

Dr Ravikumar Kurup is the Director of the Metabolic Disorders Research Centre, Trivandrum.