Pharmaceutically Relevant Microbial Enzymes

This book presents comprehensive insights into the role of microbial enzymes in disease diagnosis, treatment and pharmaceutical product development.

Enzymes from microbial origin find applications in bread, wine and vinegar production for centuries now. These biomolecules are economical and often perform under a specific pH and temperature. Enzymes such as DNA polymerase, restriction endonuclease, protease, lipase, esterase, dihydrofolate reductase, and several others find their applications in diagnostic assays, biotransformation of drugs and as an important tool in biomedical and pharmaceutical sector. For diagnostics in medical and health care, enzymes offer simple, reliable and fast assays. Additionally, due to the specificity and high-catalytic activity, the scope of enzymes is now globally extending from prediction of an illness to cure.

The book begins with comprehensive insights into the history and recent developments in the area of microbial enzymes for pharmaceutical sectors, followed by explanations on enzyme immobilization techniques for industrial applications. The subsequent chapters present the structure-function relationships of various existing microbial enzymes and explore their therapeutic activity for pharmaceutical applications. The chapters are supplemented with ample illustrations and figures for better understanding.

This is the first such book which brings various enzymes of microbial origin having pharmaceutical potential under an umbrella. This book is targeted at senior researchers like PhD Scholars, Post Doc Fellows, Scientists and faculty members in the disciplines of Medical Microbiology, Biochemistry, Molecular Biology and Pharmacy

Explores the structural, biochemical, and mechanistic aspects of various enzymes for pharmaceutical appications Compiles regulatory procedures, guidelines and policies on the usage of microbial enzymes for product developement Covers detailed case studies of enzyme based pharmaceuticals

Autorentext

Dr. Sharma is currently working as Associate Professor, University Centre For research and Development, Chandigarh University. Dr. Sharma did his PHD from CsIR-IHBT Palampur. Dr. Sharma's expertise involves exploring microbial enzymes such as antifungal proteins, multicopper oxidase, proteases, and various other enzymes for industrial application. Dr. Sharma is Associate Editor of Chemical & Biological Technologies in Agriculture (CBTA) and Academic editor of PLOS ONE. Dr Sharma already edited 3 international books and authored one lab manual. He has successfully guided 3 PhD students. Dr. Sharma also secured grant and successfully completed project as PI as well as Co-PI. He has published more than 85 research articles including research articles, review and book chapters with citation of over 1200 and H-index of 22. Dr. Sharma is reviewer of more than 60 international journals.

Dr. Salwan is currently working as Assistant Professor, Microbiology, Department of Basic Sciences, College of Horticulture and Forestry, Neri, Hamirpur. Dr. Salwan completed her PhD from Academy of Scientific and Innovative Research (AcSIR). Presently, she is Academic editor of PLOS ONE. Dr. Salwans expertise involves exploration of extremophilic microorganism for industrially relevant enzymes such as proteases and various others. She has published several research papers in journals of international reputations. Dr. Salwan has also edited 3 international books and authored one lab manual. She has published more than 80 research articles that includes research articles, review and book chapters with a total citation of over 2200 and H-index of 21. Dr. Salwan is academic editor of PLOS One and reviewer of several international journals.

Inhalt

.- Chapter 1: Introduction to Microbial Enzymes: Present Status and Future Scope in Pharmaceutical Industry
.- Chapter 2: Risk Assessment and International Biosafety Guidelines for the Enzyme Replacement Therapy in the Pharmaceutical Sector
.- Chapter 3: Microbial Uricase a potential therapeutic tool in the medical industry
.- Chapter 4: Streptokinase Evolution and its Pharmaceutical Applications
.- Chapter 5: Therapeutics Applications of Nattokinase and Collagenases
.- Chapter 6: Microbial Sacrosidase: Mechanism of Action and Its Therapeutic Applications
.- Chapter 7: Harnessing the Potential of Microbial Lactase for Treating Lactose Intolerance
.- Chapter 8: Structure and Function of Microbial Glutaminases and Their Therapeutics Applications
.- Chapter 9: Applications and Scope of Microbial L-Asparaginase
.- Chapter 10:Structure and Function of Microbial Cholesterol Oxidase and Its Applications
.- Chapter 11:Enzyme Immobilization: Present Status and Scope for Pharmaceutical Application.