Pharmacokinetic study of solid dispersion tablet of Kariyat extract

Andrographolide is poorly soluble in water, it has low oral bioavailability. Objective of present study was to enhance solubility of andrographolide through solid dispersion technique and conversion it into tablet dosage form. Solubility of extract was found to be more from solid dispersion prepared by using Soluplus than that of prepared using PEG 6000. Compatibility study using IR, DSC and XRD showed that, ethanolic extract is compatible with soluplus and can be used for preparation of stable formulation. Pharmacokinetic study showed that, there was a significant increase in absorption of andrographolide from solid dispersion tablet. andrographolide. The relative bioavailability of andrographolide from solid dispersion tablet to that of pure andrographolide was found to be 177.59±14.6%. From tissue distribution study it can be concluded that, concentration of andrographolide in all tissues get increased in animals in which solid dispersion tablet was administered orally. It reveals that absorption of andrographolide is getting increased after conversion of extract into solid dispersion tablet. Accelerated stability study indicates that prepared solid dispersion was stable.

Autorentext

O Dr. Sachin Annasaheb Nitave trabalha como director no Anil Alias Pintu Magdum Memorial Pharmacy College do Dr. J. J. Magdum Trust, em Dharangutti, Tal-Shirol, Dist-Kolhapur, Maharashtra, Índia. Obteve o primeiro lugar no exame M. Pharm da Universidade Shivaji. Publicou 63 artigos em diferentes revistas. Participou em mais de 50 acções de formação.