PHARMACOLOGICAL ACTIVITY DRIVEN SYNTHESES OF ORGANIC COMPOUNDS

ShorttitleThe research work reported in this book is
consists of synthesis of pharmacologically active
compounds and the modification of their structure
according to the result of pharmacological
screening. These compounds belongs to the classes
1,3,4-oxadiazole-2(3H)-thione, 1,3,4-thiadiazole-2
(3H)-thione, 1,3,4-oxadiazin-4H-5(6H)-one, 4-amino-
2,4-dihydro-3H-1,2,4-triazole-3-thione and 2-
imidazoline. The biological activities associated
with 1,3,4-oxadiazole-2(3H)-thione which initiate us
to synthesize these heterocyclic compounds are
discussed in chapter 1. All these compounds and some
of their intermediates were screened for different
biological activities including bactericidal,
fungicidal, phytotoxic, cytotoxic, urease inhibitory
activity and leishmanicidal activities and as
expected most of them had exhibited moderate to good
activities.The most important result is the
evaluation of the 1,3,4-oxadiazole-2(3H)-thione,
1,3,4-thiadiazole-2(3H)-thione and 4-amino-4H-1,2,4-
triazol-3-thione as potential inhibitor of the
enzyme urease.

Autorentext

I born in Pakistan and got all education from this country. I completed my Ph.D in Organic Chemistry from HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi in the year 2003. During Ph.D my Special interest was in the synthesis of simple molecules with useful biological activity.

Klappentext

ShorttitleThe research work reported in this book is consists of synthesis of pharmacologically active compounds and the modification of their structure according to the result of pharmacological screening. These compounds belongs to the classes 1,3,4-oxadiazole-2(3H)-thione, 1,3,4-thiadiazole-2(3H)-thione, 1,3,4-oxadiazin-4H-5(6H)-one, 4-amino-2,4-dihydro-3H-1,2,4-triazole-3-thione and 2-imidazoline. The biological activities associated with 1,3,4-oxadiazole-2(3H)-thione which initiate us to synthesize these heterocyclic compounds are discussed in chapter 1. All these compounds and some of their intermediates were screened for different biological activities including bactericidal, fungicidal, phytotoxic, cytotoxic, urease inhibitory activity and leishmanicidal activities and as expected most of them had exhibited moderate to good activities.The most important result is the evaluation of the 1,3,4-oxadiazole-2(3H)-thione, 1,3,4-thiadiazole-2(3H)-thione and 4-amino-4H-1,2,4-triazol-3-thione as potential inhibitor of the enzyme urease.