Pharmacological Evaluation of Poly herbal formulation on urolithiasis

Pharmacological evalution of anti-urolithiatic activity of an ayurvedic formulation Goumutradi Kshar in ethylene glycol induced urolithiasis in rats. 0.75% Ethylene glycol(EG) in drinking water for 28 days was used to induced urolithiasis in albino wister rats. Five groups (Normal Control, Disease Control, Preventive-225mg/kg, Treatment-225mg/kg, Treatment-150mg/kg) were taken & Six animals were taken in each group. An ayurvedic formulation Goumutradi Kshar was given 225mg/kg orally as prophylactic treatment & 225mg/kg & 150mg/kg orally as curative treatment. After completion of 28 days drug & EG treatment, 24hr urine, blood, kidney homogenate and kidney histopathology collections were done. It has been concluded that an ayurvedic formulation Goumutradi Kshar shows anti-urolithiatic acitivity in ethylene glycol induced urolithiasis in rats. It act as stone removal, as it inhibits crystal growth as well as it also decreased stone promoters level and increased stone inhibitor level. It has been also considered as potent diuretic since it increased urine volume in rats.

Autorentext

O Dr Jagdish Kakadiya é um académico e investigador no domínio da Farmácia há mais de 12 anos. Publicou mais de 35 artigos de investigação e revisão em revistas nacionais e internacionais. Está incluído como membro do conselho editorial, editor chefe em muitas revistas nacionais e internacionais. Tem 10 h-index, 10 i10 Index em google scholar.