Pharmacology of Endogenous Neurotoxins

It is a great pleasure to write the foreword to this important volume for several reasons. First: As far as we know, already primitive societies had to cope with environmental toxins of many kinds and set up regulations to limit their effects on food and drug use. Modem science, synthesizing tens of millions of new compounds has incredibly magnified this challenge. Today, xenobiotic metabolism has become a crucial task for humans and many other species alike. Second: When reading this book, one is impressed by the extraordinary speed at which neurotoxicology has advanced. Obviously, processing (and endogenous formation) oftox ins has become an extremely relevant topic. When I had the chance, almost three decades ago, to work in chemical pharmacology with Bernard B. Brodie at NIH, the drug metabo lizing system of the liver had just been recognized and characterized. We had just started to work on the biogenic amines, newly discovered cyclic nucleotides in rat brain, human cere brospinal fluid, and on the effects of toxic drugs like amphetamines. Today, biochemical neuropharmacology is a mature field of neuroscience.

Inhalt
A Neurotoxins.- 1 Isoquinoline Derivatives.- 2 TIQ Derivatives in the Human Central Nervous System.- 3 Animal Model of Parkinson's Disease Prepared by N-Methyl-R-Salsolinol.- 4 Putative Endogenous Neurotoxins Derived from the Biogenic Amine Neurotransmitters.- 5 ?-Carboline Derivatives as Neurotoxins.- 6 Highly Halogenated Tetrahydro-?-Carbolines as a New Class of Dopaminergic Neurons.- 7 pros -Methylimidazoleacetic Acid: A Potential Neurotoxin in Brain?.- B Metabolism.- 8 Bioactivation of Azaheterocyclic Amines Via S-adenosyl-L-methionine-dependent N-methyltransferases..- 9 Tyrosine Hydroxylase: Biochemical Properties and Short-term Regulation In Vitro and In Vivo.- 10 Tyrosine Hydroxylase and Endogenous Neurotoxins.- 11 Monoamine Oxidase: Interaction with Isoquinoline Derivatives.- 12 Toxicity and Pharmacological Effects of Salsolinol in Different Cultivated Cells.