Pharmacology of GABA and Glycine Neurotransmission

Highlighting the current developments and future directions in GABA and glycine research, this volume covers the major inhibitory neurotransmitters from the molecular mechanisms of signal transduction to their role in health and disease. It is of topical importance because these neurotransmitters are essential for brain function and therapy of diseases such as anxiety disorders, insomnias, epilepsy, depression, spasticity, and memory deficits. Distinguished scientists at the forefront of research contributed reviews on the role of these transmitters in governing neuronal networks, their signalling pathways, their receptors, the pharmacology of GABA A- and GABA B- and GABA C-receptors as well as of GABA- and glycine-transporters, and their role in disease. The volume serves as reference for pharmacologists/toxicologists, neuroscientists, neurologists and psychiatrists.

Inhalt

1. Physiology of the GABA and Glycine System. 2. The Molecular Architecture of GABA A Receptors. 3. Pharmacology and Pathophysiology of GAB A-Receptor Subtypes by Genetic Dissection. 4. Steroid Modulation of GABA A Receptors. 5. Allosteric Modulation of GABA A Receptor Function by General Anesthetics and Alcohols. 6. Anticonvulsants Acting on the GABA-System. 7. Heterologous Regulation of GABA A Receptors: Protein Phoyphorylation. 8. Tolerance and Dependence to Ligands of the Benzodiazepine Recognition Sites Expressed by GABA A Receptors. 9. GABA A Receptors and Disease. 10. GABA C Receptors: Structure, Function and Pharmacology. 11. Structure of GABA B Receptors. 12. Pharmacology of GABA B Receptors. 13. GABA B Receptor Signaling Pathways. 14. Structure and Function of GABA Transporters. 15. Pharmacology of GABA Transporters. 16. Structures, Diversity and Pharmacology of Glycine Receptors and Transporters.