Phosphonation of the C=X Functional Groups Utilizing Alkyl Phosphites

Organophosphorus compounds (OPCs) play an important role in all kinds of life. Phosphate moiety is commonly known to be a part of DNA and RNA backbones. Di- and triphosphates are considered to be the key of energy in human life as they are widely present in all living organisms. For example, they act as post-translational modification of proteins, in particular in signal transduction. Furthermore, OPCs have wide-spread biological activities and many of these compounds are analogues of natural products and act as pro-drugs. For instances, they showed to be good pharmacophore based drug design such as antibacterial and antifungal, anticancer, antiviral, antihypertensive, antitubercular, and bone seeking agents.

Autorentext

Neven A. Ganoub is a Professor of Applied Organic Chemistry at the Chemical Industries Research Division, National Research Centre. She interests with Heterocyclic Chemistry, mostly investigating some fundamental chemistry that deals with phosphorus chemistry which are likely to be biologically active and have potential in the area of medicine.