Physical Principles of Electro-Mechano-Biology

This book covers the recently developed understanding of Electro-Mechano-Biology (EMB) in which the focus is primarily on the couplings between the electric and mechanical fields. The emphasis lies on the analytical and computational aspects of EMB at the cellular level. The book is divided into two parts. In the first part, the author starts by defining and discussing the relevant basic aspects of the electrical and mechanical properties of cell membranes. He provides an overview of some of the ways analytical modelling of cell membrane electrodeformation (ED) and electroporation (EP) appears in a variety of contexts as well as a contemporary account of recent developments in computational approaches that can feature in the theory initiative, particularly in its attempt to describe the cohort of activities currently underway. Intended to serve as an introductory text and aiming to facilitate the understanding of the field to non-experts, this part does not dwell on the set of topics, such as cellular mechanosensing and mechanotransduction, irreversible EP, and atomistic molecular dynamics modelling of membrane EP.
The second (and larger) part of the book is devoted to a presentation of the necessary analytical and computational tools to illustrate the ideas behind EMB and illuminate physical insights. Brief notes on the history of EMB and its many applications describing the variety of ideas and approaches are also included. In this part, the background of the first principles and practical calculation methods are discussed to highlight aspects that cannot be found in a single volume.

Covers first-principles and experimental check Provides a comprehensive review for biologists who want to understand physics and mechanics Useful for computational researchers working in biophysics

Autorentext

Christian Brosseau is a distinguished professor at the Department of Physics, Université de Bretagne Occidentale, Brest, France. From 2010-present, he leads the wave-matter interaction modelling and simulation group at the Department of Physics of the Université de Bretagne Occidentale and supervises Ph.D. students and postdoctoral research associates. His current interests include electromagnetic wave propagation in complex media, plasmonics, nanophysics, biological physics, computational materials physics, and polarization optics and image processing. Fellow of Optica, Fellow of the Institute of Physics, Dr. Brosseau has been recognized through numerous awards, including the 2017 SPIE G. G. Stokes Award. He is the author of the book "Fundamentals of Polarized Light: A Statistical Optics Approach" and editor of the book "Prospects in Filled Polymers Engineering: Mesostructure, Elasticity Network, and Macroscopic Properties".

Klappentext

This book covers the recently developed understanding of Electro-Mechano-Biology (EMB) in which the focus is primarily on the couplings between the electric and mechanical fields. The emphasis lies on the analytical and computational aspects of EMB at the cellular level. The book is divided into two parts. In the first part, the author starts by defining and discussing the relevant basic aspects of the electrical and mechanical properties of cell membranes. He provides an overview of some of the ways analytical modelling of cell membrane electrodeformation (ED) and electroporation (EP) appears in a variety of contexts as well as a contemporary account of recent developments in computational approaches that can feature in the theory initiative, particularly in its attempt to describe the cohort of activities currently underway. Intended to serve as an introductory text and aiming to facilitate the understanding of the field to non-experts, this part does not dwell on the set of topics, such as cellular mechanosensing and mechanotransduction, irreversible EP, and atomistic molecular dynamics modelling of membrane EP. The second (and larger) part of the book is devoted to a presentation of the necessary analytical and computational tools to illustrate the ideas behind EMB and illuminate physical insights. Brief notes on the history of EMB and its many applications describing the variety of ideas and approaches are also included. In this part, the background of the first principles and practical calculation methods are discussed to highlight aspects that cannot be found in a single volume.

Inhalt

Part 1. Background.- Chapter 1. Elementary concepts and definitions.- Chapter 2. A Brief Sketch of the History of EMB: Where Good Ideas Come From.- Part 2. Calculation Methods.- Chapter 3. Supramolecular Analytical Approaches of EMB.- Chapter 4. Computational approaches of EMB.- Generic Final Remarks.- Challenges Ahead.