Phytochemical Investigations on Constituents of Medicinal Plants

This book describes the phytochemical investigations carried out on two indigenous medicinal plants of Pakistan namely, Isatis costata and Leucas urticifolia. Part A is about the isolation and structure elucidation of five new alkaloids named as costinone A, costinone B, isatinone A, isatinone B and isamide. In addition, five known compounds caffeic acid ester, docosyl caffeate, methyl-2 acetoamidobenzoate, -sitosterol and ursolic acid have also been isolated and characterized for the first time from this species. Compounds costinone A and costinone B inhibited lipoxygenase and butyrylcholinesterase enzymes non-competitively in concentration-dependent fashion with promising inhibitory potentials. Compounds isatinone A and isatinone B showed vital antifungal activity. Part B describes the isolation and structure elucidation of two new compounds named as leucisterol and urticic acid, along with four known compounds named as 2-methoxybenzyl benzoate , 4-hydroxy benzoic acid , -sitosterol and ursolic acid which are reported first time from this species. The compound leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.

Autorentext

Dr. Itrat Fatima obtained PhD in 2010 from University of Karachi, Pakistan. She has authored/co-authored over 40 scientific publications and a winner of Research Productivity Awards in 2012 and 2013. Her research interests are the areas of isolation and spectroscopic analysis of new biological active compounds in medicinal plants of Pakistan.