Polar Surface Area
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Details
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The polar surface area (PSA) is defined as the surface sum over all polar atoms, (usually oxygen and nitrogen), including also attached hydrogens.PSA is a commonly used medicinal chemistry metric for the optimisation of cell permeability. Molecules with a polar surface area of greater than 140 angstroms squared are usually believed to be poor at permeating cell membranes. For molecules to penetrate the blood-brain barrier (and thus acting on receptors in the central nervous system), PSA should be less than 60 angstroms squared.
Weitere Informationen
- Allgemeine Informationen
- GTIN 09786131050862
- Editor Lambert M. Surhone, Miriam T. Timpledon, Susan F. Marseken
- Genre Chemie
- Größe H220mm x B220mm
- EAN 9786131050862
- Format Fachbuch
- Titel Polar Surface Area
- Herausgeber Betascript Publishing
- Anzahl Seiten 80
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