Polyphenols-based Nanotherapeutics for Cancer Management

This book reviews the applications of polyphenols in cancer treatment. The initial chapter of the book classifies different polyphenols and discusses their biological and chemical properties. The subsequent chapters then explore the diverse role of polyphenols in modulating signal transduction pathways in cancer including, cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, and metastasis. This book highlights the usefulness of polyphenol enriched seafood in modulating the anti-tumor and anti-inflammatory cytokine IFN-. The book also presents nanoformulation of polyphenol as a promising strategy for their enhanced bioavailability and targeted delivery. Lastly, the book examines the toxicity and safety evaluations of polyphenols as anticancer agents.

Highlights the role of polyphenols in cancer management Reviews molecular mechanisms of modulating signaling pathways by polyphenols in cancer Examines polyphenols-enriched seafood in modulating anti- and pro-inflammatory cytokines

Autorentext
Prof. Shams Tabrez is working as a Professor of Biochemistry at King Fahd Medical Research Center, King Abdulaziz University (KAU). Earlier, he has obtained Ph.D. in Biochemistry from Aligarh Muslim University (AMU), India. His research is focused on cancer chemoprevention using bioactive compounds and the improvement of their delivery by nanotechnology-based techniques. He also has a strong research interest in the field of metabolomics and enzymology. He has published more than 130 articles in journals of high repute. Prof. Tabrez is serving and/or served as an editorial board member of several journals, including Current Pharmaceutical Design, Current Clinical Pharmacology, Cells, Current Vascular Pharmacology, and Pharmacognosy Magazine.
Dr. Mohammad Imran Khan is an Associate Professor in the Department of Biochemistry at KAU, Saudi Arabia. He obtained his Ph.D. in Medical Biochemistry from CSIR-Indian Institute of Toxicology Research (CSIR-IITR) and Aligarh Muslim University (AMU), India, and did post-doctoral training from the University of Wisconsin, Madison. His research interest includes nano-chemoprevention, epigenetics, and metabolomics. He has published more than 60 research articles in the journals of international repute.

Inhalt

Chapter 1 Introduction and classification of natural polyphenols **.- Chapter 2 Polyphenol intakes and risk of cancer: An epidemiological scenario .- Chapter 3 Polyphenols-based prevention and therapeutics in different cancers .- Chapter 4 Effect of polyphenols on signaling pathways .- Chapter 5 Role of polyphenols in modulating gene expression in different cancers .- Chapter 6 Effect of polyphenols on Inflammation and immune response in cancer .- Chapter 7 Epigenetic basis of polyphenols in cancer prevention and therapy .- Chapter 8 Polyphenols and cancer stem cells (CSCs) .- Chapter 9 Polyphenols as modulator of oxidative stress in cancer disease .- Chapter 10 Development of novel therapeutics for enhanced polyphenol delivery .- Chapter 11_** Toxicological concern of different bioactive polyphenols as anticancer agents.