Post-Transplant Lymphoproliferative Disorders

Post-transplant lymphoproliferative disorders straddle the border between infection and malignancy and develop in five to ten percent of transplant recipients. This book details every aspect of these disorders ranging from basic science to clinical topics.

Post-transplant lymphoproliferative disorders are a group of conditions that straddle the borders between infection and malignancy. They were very rare prior to the mid-1980s but now can be expected to develop in 1-10% of transplant recipients. While some cases are reversible with reduction in immunosuppression, more severe forms are indistinguishable from frank lymphomas.

This book sets out to cover in depth every aspect of these disorders, including both basic science and clinical topics. The epidemiology is reviewed, and careful attention is paid to the role of Epstein-Barr virus in their development. Clinical features are documented and clear guidance is provided on diagnosis, with thorough description of pathologic and imaging findings. Further chapters are devoted to treatment, prognosis, preventive and pre-emptive strategies, and organ-specific considerations.

The state-of-the-art information contained in this book will aid researchers as well as the many different professionals involved in caring for patients with post-transplant lymphoproliferative disorders. The comprehensive and detailed coverage will appeal to those who already have some expertise in the field, yet the book will also serve as an invaluable resource for beginners in transplantation.

Explores in detail every aspect of post-transplant lymphoproliferative disorders, which can be expected to develop in 5-10% of transplant recipients Discusses the role of Epstein-Barr virus, documents clinical and pathological features, and assesses treatment options Designed to aid the different professionals who care for patients with post-transplant lymphoproliferative disorders, whether beginners or experts Includes supplementary material: sn.pub/extras

Inhalt
Historical Perspective on the Early Studies of Posttransplant Lymphoproliferative Disorders (PTLD).- Epidemiology of PTLD.- The Biology of EpsteinBarr Virus and Posttransplant Lymphoproliferative Disease.- EpsteinBarr Viral Load Testing: Role in the Prevention, Diagnosis and Management of Posttransplant Lymphoproliferative Disorders.- Clinical Features and Diagnostic Evaluation of Posttransplant Lymphoproliferative Disorder.- Pathology.- Prognostic Factors for PTLD.- Treatment of PTLD.- Prevention of EpsteinBarr Virus Infection and Posttransplant Lymphoproliferative Disease Following Transplantation.- Organ Specific Issues of PTLD Kidney.- Posttransplantation Lymphoproliferative Disorder (PTLD) in Liver and Small Bowel Transplant Recipients.- Heart and Lung Transplantation.- Posttransplant Lymphoproliferative Disease (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT).- Research Priorities and Future Directions.