Preparation and Antimicrobial Activity of Chalcone Bound Pyrimidines

This book is very useful for the researcher and academia who are working on Pyrimidine derivatives. This book deals with spectroscopic characterization of synthesized pyrimidines. This books contain one separate chapter for antimicrobal activity. All synthesized compounds were tested for their microbial screening. The synthesis of chalcones was carried out by one pot condensation of 1-chloro-(4-tolyloxy) benzene with 1-(4-hydroxylphenyl) ethanone followed by condensation with various aromatic aldehydes. Prepared chalcones were refluxing with guanidine to yields various pyrimidine derivatives. All the prepared compounds were characterized in by 1H NMR, 13C NMR, IR, MASS spectroscopic techniques. Biological evaluation of mention compounds was also made in terms of gram positive bacteria such as Staphylococcus aureus, Bacillus megaterium and gram negative bacteria Escherichia coli, Proteus vulgaris.

Autorentext

La Dra. Mikita Shah ha realizado su maestría en la Universidad de Gujarat y su doctorado en la Universidad del Pacífico, en Rajastán. El Dr. Bhaumikkumar Patel hizo su maestría en la Universidad de Gujarat y su doctorado en la HNGU, Patan. El Sr. Vikramsinh Chauhan ha hecho su M.Sc. de la Universidad de Gujarat & Actualmente persigue el doctorado de la misma Universidad. Todos los autores tienen buenas habilidades en Med. Chem.