Primary Aldosteronism

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene KCNJ5 in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.

Presents Primary Aldosteronism (PA) from pathophysiology to quality of life aspects, covering genetics, diagnostics, different treatments in a truly translational manner Discusses what is needed for the development of care of individuals with PA Explores recent developments in understanding the genetics behind sporadic PA that may lead to novel methods to diagnose the disease in the future Includes supplementary material: sn.pub/extras

Inhalt

Introduction.- Primary Aldosteronism: Molecular Mechanisms and Diagnosis.- Epidemiology and need for screening.- Low renin hypertension.- Molecular derangements in sporadic primary aldosteronism.- From genetic abnormalities to pathophysiological mechanisms.- Familial hyperaldosteronism type I.- Familial hyperaldosteronism type II.- Familial hyperaldosteronism type III.- The Aldosterone-renin ratio role and problems.- Confirmatory testing for Primary Aldosteronism.- Radiological imaging of adrenocortical tumors.- Aldosterone and cardiovascular disease.- Quality of life aspects of primary aldosteronism.- Medical treatment of primary aldosteronism.- Surgical treatment of primary aldosteronism.- Index.