Prion Diseases

Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts Includes supplementary material: sn.pub/extras

Inhalt

Kuru: Introduction to Prion Diseases.- Anthropological Methods used in Kuru Research.- Nonhuman Primates in Research on Transmissible Spongiform Encephalopathies.- Clinical Features and Diagnosis of Human Prion Diseases.- Neuropathology, Immunohistochemistry, and Biochemistry in Human Prion Diseases.- Sub-Cellular and Molecular Changes Associated with Abnormal PrP Accumulation in Brain and Viscera of Classical and Atypical Prion Diseases.- Electron Microscopy of Prion Diseases.- Cell Death and Autophagy in Prion Diseases.- Methods for Isolation of Spiroplasma sp. from Prion Positive Eye Tissues of Sheep Affected with Terminal Scrapie.- Detection and Diagnosis of Prion Diseases using RT-QuIC: An Update.- Analysis of Charge Isoforms of the Scrapie Prion Protein using Two-Dimensional Electrophoresis.- Exosomes in Prion Diseases.- Synthetic Mammalian Prions.- Biomarkers in Cerebrospinal Fluid.- The Use of Transgenic and Knock Out Mice in Prion Research.- Transgenic Mouse Models of Prion Diseases.<p