Process Development of Amlodipine and Olmesartan Medoxomil Tablets

The present study was focused on process development of amlodipine and olmesartan medoxomil tablet 10/40mg. Amlodipine and Olmesartan medoxomil is a combination of a calcium channel blocker and an angiotensin II receptor antagonist used to treat high blood pressure . The Content uniformity was found of both the drugs were performed. Release study was conducted in pH 6.8 buffer media. Furthermore, dissolution profile comparison was carried out using similarity factor (f2) and the similarity factor of Amlodipine and Olmesartan Medoxomil found to be 73. Other studies Like DSC and FTIR studies reported compatibility of Amlodipine besylate with excipients like Cross Carmel lose sodium was performed shows no chemical interaction between drug and excipients. Dissolution profile of Test and Reference standard found to be similar, Similarity factor (f2) is 73.

Autorentext

Ms. Gayatri Behera M. Pharm is working as an Assistant Professor at School of Pharmacy , Centurion University Of Technology , Odisha. She is actively involved in research methodology. MS. Binapani Barik M. Pharm is working as an Assistant Professor at School of Pharmacy , Centurion University Of Technology , Odisha.