Project of Gurbakhshish Singh - Growth Retardation in EHPVO

Extrahepatic portal vein obstruction (EHPVO) is an important cause of noncirrhotic portal hypertension in the developing countries (up to 30% of all variceal bleeders) and is second to cirrhosis in the West (up to 5 10%). EHPVO is also the most common cause of upper gastrointestinal bleeding in children. It accounts for almost 70% of pediatric patients with portal hypertension. EHPVO occurring in the pre-pubertal period could result in growth retardation in around 50% of the children. Reduced portal blood supply to the liver, resistance to growth hormone function and reduced insulin-like growth factor has been hypothesized for growth retardation. This study aimed to find out whether digestive or endocrine abnormality is responsible for growth retardation in EHPVO.

Autorentext

Sonia B. Bhardwaj, doctora: Profesora adjunta en HSJIDS, Chandigarh, India. Chander K. Nain, PhD: Profesor del PGIMER, Chandigarh; Kaushal K. Prasad, MD, PDCC: Profesor asociado; Saroj K. Sinha, MD, DM: Profesor asociado; Arun K. Sharma, MD: Profesor asociado; Kartar Singh, MD, DM: Profesor titular y director.